Percy Lavon Julian
Percy Julian was born in Montgomery, Alabama, first child of six born to James Sumner Julian and Elizabeth Lena Julian Both of his parents were graduates of what was to be Alabama State University. His father, a railroad mail clerk, and his mother, a school teacher stressed education to their children. This emphasis would ultimately prove successful as two sons went on to become physicians and three daughters would receive Masters degrees, but it was son Percy who would become the most successful of the children.
Percy Lavon Julian April 11, 1899 – April 19, 1975 was an African American research chemist and a pioneer in the chemical synthesis of medicinal drugs from plants. He was the first to synthesize the natural product physostigmine, and a pioneer in the industrial large-scale chemical synthesis of the human hormones progesterone and testosterone from plant sterols such as stigmasterol and sitosterol. His work laid the foundation for the steroid drug industry's production of cortisone, other corticosteroids, and birth control pills.
After college, Julian accepted a position as a chemistry instructor at Fisk University. He left in 1923 when he received a scholarship to attend Harvard University to finish his master’s degree, though the university would not allow him to pursue his doctorate. He traveled for several years, teaching at black colleges, before obtaining his Ph.D. at the University of Vienna in Austria in 1931.
In the 1930s chemists recognized the structural similarity of a large group of natural substances—the steroids. These include the sex hormones and the cortical hormones of the adrenal glands. The medicinal potential of these compounds was clear, but extracting sufficient quantities of them from animal tissue and fluids was prohibitively expensive. As with other scarce or difficult-to-isolate natural products, chemists were called upon to mimic nature by creating these steroids in the lab and later by modifying them to make them safer and more effective as drugs.
He later started his own company to synthesize steroid intermediates from the wild Mexican yam. His work helped greatly reduce the cost of steroid intermediates to large multinational pharmaceutical companies, helping to significantly expand the use of several important drugs.
Julian received more than 130 chemical patents. He was one of the first African Americans to receive a doctorate in chemistry. He was the first African-American chemist inducted into the National Academy of Sciences, and the second African-American scientist inducted (behind David Blackwell) from any field.
Desiring to leave academia, Julian applied for jobs at prominent chemical companies, but was repeatedly rejected when hiring managers discovered that he was black. Ultimately, he obtained a position at Glidden Company as the lab director. There he invented Aero-Foam, a product that uses soy protein to put out oil and gas fires and was widely used in World War II, as well as other soybean-based inventions.
Julian continued his biomedical work as well, and discovered how to extract sterols from soybean oil and synthesize the hormones progesterone and testosterone. He was also lauded for his synthesis of cortisone, which became used in the treatment of rheumatoid arthritis.
Julian left Glidden in 1953 and established his own laboratory, Julian Laboratories, in 1954. He sold the company in 1961, becoming one of the first black millionaires, before founding Julian Research Institute, a nonprofit organization that he ran for the rest of his life.
PBS NOVA S34E08 Forgotten Genius
Information sources:
www.sciencehistory.org/historical-profile/percy-lavon-julian
blackinventor.com/percy-julian/
www.biography.com/people/percy-julian-9359018
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